Moducare Vegetarian Capsules

MODUCARE

90caps

Micro-Nutrients for the body's immune system help your body to help itself. ------------------------------------------------------------------- "Moducare may be of benefit for ..... The human body contains a miraculous healing machine called the immune system. Made up of microscopic cells it identifies, remembers, attacks and destroys disease causing invaders and abnormal or infected cells. The immune system also plays a significant role in helping prevent, or allaying the effects of, degenerative disease, allergies, arthritis, asthma… and so much more. To do all these things the immune system needs to be in balance. Internationally recognized research using Moducare®, shows that this proprietary extraction of plant nutrients helps to bring overall balance to your immune system. A balanced immune system allows you to enjoy vibrant health. Moducare is not a drug. Moducare is not a herb. Moducare is not a probiotic. Moducare is simply a food supplement. Moducare's nutrients have been researched over a 34 year period. Moducare does not boost the immune system. Moducare does not supress the immune system. Moducare food supplement helps modulate the immune system. ------------------------------------------------------------------- The Science of Moducare Moducare- A Brief History and Mode of Action Moducare® is a mixture of sitosterol* (BSS) and its glucoside sitosterolin (BSSG) in a 100:1 ratio. This formulation was originally marketed in 1974 in Germany, after its beneficial effect in the treatment of benign prostate hypertrophy (BPH) had been established. Two years later, the same BSS/BSSG mixture was marketed in a product for rheumatoid arthritis. In 1989, Professor Patrick Bouic and his colleagues at the Medical School of the s, South Africa discovered that both sitosterol and sitosterolin have an immune modulating effect. Their findings, which were published in the Int J of Immunopharmacology 1996, 18, 693-700, eventually resulted in the patented product called Moducare®. Moducare® taken orally at 3 capsules per day (each capsule contains 20.2 mg sterols/sterolins) restores weakened or reduced T cell activity in a balanced proportion of TH1 and TH2 cells. This enables the immune system to effectively counteract viral diseases (common cold, hepatitis, HIV, etc.) and various microbial diseases (tuberculosis, etc.). Moducare® also corrects a variety of autoimmune conditions (e.g. rheumatoid arthritis) usually arising from an excess secretion of inflammatory factors. However, Moducare® is not a drug: it does not interfere with any metabolic processes of either the patient or an infecting agent but it is rather a catalyst or messenger initiating a correction of existing immune system imbalances or maintaining adequate existing balances. It thereby helps an individual to maintain good health or fight a disease effectively. The use of Moducare® is ideal in conjunction with drug treatments that tend to disturb the TH1:TH2 balance or where a disease results in a TH1:TH2 imbalance which a drug cannot correct. *sitosterol: This compound is usually described in the literature as ß-sitosterol or beta-sitosterol. The chemical name is often shortened to “sterol”. Dr. Karl H. Pegel, CChem, FRSC Associate Professor (Retired), School of Pure and Applied Chemistry University of Natal, Durban, South Africa ------------------------------------------------------------------- Moducare Veg Caps Directions: Take 3 capsules daily to supplement a healthy varied diet. For best results take one capsule one hour before meals or two hours after a meal, do not exceed the recommended daily intake. Food supplements should not be used as a substitute for a varied diet. powder can be emptied from capsule shell and mixed with fruit juice or sauce. Do not mix with milk, yoghurt or animal derived products. ------------------------------------------------------------------- Presentation: Vegetarian clear capsule shell containing a white insoluable powder. One original pack contains 84 capsules (one month supply at normal dosing). Ingredient Amount per Lozenge Upper Safe Daily Limit (USDL) Percentage USDL ß-Sitosterol 20mg 3000mg 0.6666% ß-Sitosterolin 0.2mg 3000mg 0.006% Ingredients: Magnesium Silicate (vegetarian), Plant sterols and sterolins. (plant sterols and sterolins are isolated from Pinus maritime and Pinus pinaster) Does not contain: soy, sugar, acacia, barley, wheat, corn, millet, lactose, yeast, gluten, artifical sweetners or colourings, flavourings, dairy, animal products or preservatives. Storage: Store below 25°C. store in dry conditions, do not store in kitchen or bathroom. Keep out of reach of children. Best before end/ batch number: see base of bottle. ------------------------------------------------------------------- Moducare use in Bacterial, Fungal, Yeast, Viral and Mycobacterium infections. Moducare use in Bacterial, Fungal, Yeast, Viral and Mycobacterium infections. Tuberculosis (TB) In a double-blind controlled study, the use of sterols/sterolins as adjunctive therapy helped TB patients recover faster, gain more weight, and exhibit less inflammation than those taking a placebo. Donald PR, et al: A randomised placebo-controlled trial of the efficacy of beta-sitosterol and its glucoside as adjuvants in the treatment of pulmonary tuberculosis. Int J Tuberc Lung Dis 1997; 1: 518-22 -------------------------------------------------------------------------------- HIV Infection In an open label study, HIV positive patients with CD4 cell counts above 500 cells/µl blood and who were not using antiretroviral drug therapy showed stable CD4 cells counts and a decrease in their plasma viral loads after employing the BSS:BSSG mixture for up to 40 months. This group of patients maintained a predominantly TH1 profile indicating that their cell mediated immunity response accounted for both their viral control and prevention of CD4 cell loss. Human Immunodeficiency Virus (HIV) Study scientific abstract. Reference: Bouic PJD, Clark A, Brittle W, Lamprecht JH, Freestone M, Liebenberg RW. Plant sterol/sterolin supplement use in a cohort of South African HIV-infected patients—effects on immunological and virological surrogate markers. South African Med J 2001; 91: 848–50. Study: In an open label pilot study, 123 HIV positive patients (who were not on any retroviral medications) were given a proprietary mixture of sterol/sterolin supplement (Moducare®) on a daily basis over a period of 39 months. Subjects who participated in this study were evaluated at 0, 1, 2, 3 months and then every four months thereafter for body mass, concomitant conditions (e.g. opportunistic infections), CD4 lymphocyte cell count and viral loads. For study purposes, patients were stratified into 3 groups based on CD4 counts at the beginning of the trial: CD4 < 200/µl (n = 10), CD4 200 – 500/µl (n = 66), CD4 > 500/µl (n = 47). Results: Patients with a CD4 count of less than 200/µl showed a significant reduction in the median percentage and absolute numbers of CD4 cells/µl from baseline values of 11% and 134 CD4/µl to 7% and 23 CD4/µl respectively after 21 months. However, despite this first group’s decrease in immunologically active CD4 cells, there was no significant change in the patients’ viral load from baseline (4.23 log) to the end of the trial (4.60 log) period. Similarly, patients in Group 2 whose CD4 count was between 200 – 500/µl, showed no significant changes in median CD4 percentage (19% at baseline compared to 18.5% at completion), median CD4 count (349 versus 275/µl) and plasma viral load (5.06 log in contrast to 5.15 log) during the 39 months they were evaluated.Like the outcomes seen in the other two groups, patients in the third and most immunologically stable group (CD4 > 500/µl) exhibited no changes in their CD4 immune markers. They did however have a significant reduction in plasma viral load of 1.48 log from 4.59 log at the beginning of the study to 3.11 log at 30 months. Moreover, 15% (7/47) of patients within this group had no detectable plasma viral count after 12 months of therapy with plant sterols/sterolins. Clinical Summary: Although these results should be confirmed in a controlled clinical trial, HIV positive patients whose CD4 count is above 500/µl may be able to stabilize their CD4 cell counts and reduce their viral load through the judicious use of a plant sterol/sterolin mixture (Moducare®) at a dose of 1 capsule 3 times a day between meals. Additional reference: Breytenbach, U. et al: Flow cytometric analysis of the Th1-Th2 balance in healthy individuals and patients infected with the human immunodeficiency virus (HIV) receiving a plant sterol/sterolin mixture. Cell Biol Int 2001; 25, 43-49. -------------------------------------------------------------------------------- Preparation of the immune system by Immune Modulation This showed that the immune system can be modulated or normailsed using in vivo methods and in vitro methods. The study showed how moducare could be used to maintain a healthy immune system especially when preparing for a season where there is high risk of cold and flu infection. Reference: Bouic PJD, Etsebeth S, Liebenberg RW, Albrecht CF, et al. Beta-sitosterol and beta-sitosterol glucoside stimulate human peripheral blood lymphocyte proliferation: implications for their use as an immunomodulatory vitamin combination. Int J Immunopharm 1996; 18:693–700. Study: In this paper, the immunological actions of sterols/sterolins (Moducare®) were considered by both in vitro and in vivo experiments. In the first in vitro study, venous blood was drawn from healthy laboratory volunteers and employed as a source of T cells. These T cells were added to cell cultures and incubated along with 3H-thymidine and stimulated suboptimally with a mitogen for 72 hours. Varying concentrations of beta- sitosterol (BSS), beta-sitosterol glucosides (BSSG), and a 100:1 ratio of BSS/BSSG (Moducare®) were then added to these mixtures and laboratory markers of immune response such as T cell proliferation, CD25 and HLA-DR activation, IL-2 secretion, gamma interferon release, and natural killer (NK) cell activity were recorded. In the in vivo portion of the trial, six volunteers ingested one capsule of Moducare® (20mg BSS and 0.2mg BSSG) 3 times a day for four weeks. Two volunteers were given placebo capsules at the same dosing schedule. Blood samples were collected at 0, 1, 2 and 4 weeks. The resulting T cells were incubated with 3H-thymidine and stimulated maximally with the PHA mitogen allowing the researchers to evaluate T cell proliferation at baseline and day 30. Results: In vitro results demonstrated that although both phytosterols (BSS and BSSG) enhance the proliferative response of T cells to mitogen stimulation at very low concentrations, a 100:1 ratio of BSS to BSSG provided a larger stimulatory effect than could be achieved by the individual phytosterols and sterolins alone. Moducare® at a concentration of 1 µg/ml was able to double the expression of CD25 and HLA-DR activation antigens on T cells, and increase the secretion of IL-2 (ranging from 17 to 23%) and gamma interferon (ranging from 36 to 41%) compared to controls. In addition, the combination of BSS/BSSG (100:1) at 1 µg/ml was consistently more active at stimulating the lytic action of NK cells (effector) on a cancer K562 cell line (target) than BSS or BSSG on their own. Different effector:target ratios were tested ranging from 12,25,50 and 100:1 and for all these cell ratios the BSS/BSSG stimulated NK cells were the most effective. In vivo results from the eight volunteers concluded that compared to baseline values, T cell proliferative responses increased from 20 to 920% in those taking Moducare® over 4 weeks compared to a relatively unchanged (–2 to 13%) reaction in the placebo group. Clinical Summary: The unique combination of plant sterols/sterolins as found in the product Moducare® significantly enhances the laboratory markers of immunity both in vitro and in vivo. -------------------------------------------------------------------------------- Reference: Bradford PG, Awad AB. Phytosterols as anticancer compounds. Mol Nutr Food Res 2007;51:161-170. Review: Phytochemicals have been proposed to offer protection against a variety of chronic ailments including cardiovascular diseases, obesity, diabetes, and cancer. As for cancer protection, it has been estimated that diets rich in phytochemicals can significantly reduce cancer risk by as much as 20%. Phytosterols are specific phytochemicals that resemble cholesterol in structure but are found exclusively in plants. Phytosterols are absorbed from the diet in small but significant amounts. Epidemiological data suggest that the phytosterol content of the diet is associated with a reduction in common cancers including cancers of the colon, breast, and prostate. The means by which dietary phytosterols may be achieving these effects is becoming clearer from molecular studies with tumorigenic research models. Phytosterols affect host systems potentially enabling more robust antitumor responses, including the boosting of immune recognition of cancer, influencing hormonal dependent growth of endocrine tumors, and altering sterol biosynthesis. In addition, phytosterols have effects that directly inhibit tumor growth, including the slowing of cell cycle progression, the induction of apoptosis, and the inhibition of tumor metastasis. Summary: This review summarizes the current state of knowledge regarding the anticancer effects of phytosterols."

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